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2012 - Traudi Klein

Ph.D. Thesis


Author: Traudi Klein

Postgraduate Program in Pharmaceutical Sciences - State University of Maringá

Area of Knowledge: Pharmacognosy

Date of Defense: February 02, 2012

Advisor: Prof. Dr.  João Carlos Palazzo de Mello

Examination Board:  Prof. Dr. Antônio Medina Neto

                            Prof. Dr. Diva Sonaglio

                            Prof. Dr. Maria Palmira Daflon Gremião

                            Prof. Dr. Norberto Peporine Lopes

                            Prof. Dr. Rubiana Mara Mainardes


Title: Development of analytical and technological methodology for Paullinia cupana var. sorbilis (Mart.) Ducke – Sapindaceae tablets

Abstract: Guaraná seeds of Paullinia cupana var. sorbilis (Mart.) Ducke, is widely used in food and pharmaceutical market in Brazil and elsewhere. Its seeds contain high concentrations of methylxanthines such as caffeine, theobromine and theophylline, saponins and polyphenols, especially tannins. The antidepressant effect has been evaluated with promising results comparable to the tricyclic antidepressant imipramine. But there is still no commercially available pharmaceutical form of guarana extract obtained from the standard drug. The chemical standardization of EPA semipurified extract was performed on the basis of chemical markers catechin and epicatechin by HPLC. Phytomedicines tablets require high care production, mainly due to the hygroscopic properties and chemical instability of the raw materials of plant origin. And to avoid the problem of chemical instability of the production of microparticles from the semipurified extract for subsequent production of tablets are presented as a great advantage to the protection of plant active constituents of the action of environmental agents such as light and moisture. EPA microparticles were produced by spray drying using maltodextrin and arabic gum as polymeric materials and characterized by morphology, particle size, thermal analysis, antioxidant activity and dissolution test. This study aimed the development of analytical methodology and technology in achieving standardized extract and tablets of P. cupana var. sorbilis. EPA tablets were produced from microparticles containing the semipurified extract and these were characterized by powders flow studies, appearance, hardness, friability, disintegration and dissolution test. The methodology used was suitable for production of guarana tablets.

KeywordsPaullinia cupana, Sapindaceae, guaraná, extract validation, tablets, standardization.



Thesis PDF: Traudi Klein


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